PHARMACOKINETICS
NO METABOLISM FOR ACTIVE DRUG
Motofen contains the active metabolite, difenoxin, and does not need to be converted in the liver. Motofen is rapidly and extensively absorbed, reaching peak plasma levels in 40 to 60 minutes.2
PEAK PLASMA LEVELS
After a Motofen dose of 2 mg, the approximate peak plasma level of 160 ng/mL was reached.2 Lomotil reached an approximate peak plasma level of 163 ng/mL after a 10-mg dose.3 Approximately the same peak plasma level was obtained for both drugs; however, the Motofen dose was one-fifth that of Lomotil. Studies have shown that difenoxin is five times as potent as diphenoxylate with a similar side-effect profile.1
